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The spontaneously diabetic “bb” wistar rat was examined for evidence of peripheral nerve abnormalities by a combined morphologic and physiologic approach. The studies were done on rats kept severely hyperglycemic and frequently ketotic.
T he acute onset of insulin-dependent diabetes mellitus (iddm) in the b8 wistar rat is asso- ciated with inflammatory lesions of the pancreatic islets and a marked pancreatic b cell necrosis. 12 the inflammatory lesion or insulitis which resembles that of iddm in man often precedes the onset of iddm in the bb rats)'4 lnsulitis was recently found to be associated with a peripheral blood lymph ocytopenia dmbettc rats but also m rats wtthout not only in overtly ' detectable metabolic.
The spontaneously diabetic bb rat, discovered serendipitously in 1974 in a commercial breeding facility (bireeding laboratories, ottawa, ontario), is an animal model that displays clinical and pathologic features closely resembling type 1 (insulin-dependent, juvenile-onset) diabetes meilitus in humans.
Spontaneous diabetic bb rat: studies of cyclic adenosine 3',5'-monophosphate phosphodiesterase and calmodulin. Uncontrolled diabetes in man is associated with increased plasma and tissue levels of camp and decreased camp phosphodiesterase (pde) activity. Spontaneously diabetic bb rats (sdr) were used in these experiments.
The three major well-established spontaneous rat models are the biobreeding (bb) diabetes-prone rat, the komeda diabetes-prone (kdp) rat, and the iddm (lew.
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Studies prior to and during development of the overt syndrome. Spontaneous gastric erosions and ulcerations in bb wistar rats.
To determine the influence of infectious agents on the initiation of diabetes in the spontaneously diabetic bio-breeding/worcester (bb/w) rat, susceptible rats were raised in a germ-free environment. Histologic examination of the pancreas revealed insulitis or end-stage islets. Culture and smears from various tissues were negative for bacteria or parasites.
The spontaneously diabetic bb rat: sites of the defects leading to autoimmunity and diabetes mellitus. Author information: (1)department of pediatrics, university of virginia school of medicine, charlottesville 22908.
Like summary to determine the influence of infectious agents on the initiation of diabetes in the spontaneously diabetic bio-breeding/worcester (bb/w) rat, susceptible rats were raised in a germ-free environment.
All rats with pancreatic insulitis (a manifestation of the onset of diabetes) also had thyroiditis. Bb wistar rats with insulitis had more severe lymphocytic thyroiditis,.
Caldwell” and neurobiology, university of tennessee, 875 monroe, memphis, and *department of anatomy, the medical college of georgia, augusta, georgia 30912 received march 23, 1989 endothelial cell permeability and luminal surface anionic sites were studied in the retinal microvasculature of spontaneously diabetic rats.
Myocardial fatty acid metabolism was studied in spontaneously-diabetic bb wistar rats. The study involved 4 groups: control wistar rats, nondiabetic littermates.
(1983) the discovery and development of the bb rat colony: an animal model of spontaneous diabetes mellitus.
Jun 28, 2008 we used the type 1 diabetic biobreeding (bb)‐rat model to study jejunal in the jejunum of spontaneously diabetic rats, decreased nitric oxide.
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The purpose of this investigation was to examine cardiac function and biochemistry in spontaneously diabetic bb rats, a strain in which diabetes occurs spontaneously and closely resembles insulin-dependent diabetes in humans.
Apoptosis and disease progression in the spontaneously diabetic bb/s rat type i (insulin-dependent) diabetes mellitus is an autoimmune disease culminating in pancreatic beta-cell destruction. A role for apoptosis in this destruction has been suggested, although controversy exists over the identity of the apoptotic cells and the time of onset of apoptosis.
In two diabetes-prone bb rat strains, 19 animals developed diabetes with onset between 50 and 120 days. In rats developing diabetes between 50 and 85 days of age, 7 of 9 animals presented icsa at clinical onset, determined by either the immunofluorescence or cytotoxicity test.
The spontaneously diabetic bb rat is an authentic model of human insulin-dependent diabetes melli- tus (iddm) and as such develops the whole spec- trum of functional.
It has been assumed that idiopathic megacolon occurring in the spontaneously diabetic bb rat results from metabolic decompensation associated with diabetes. In a large prospective necropsy study we have documented the incidence of idiopathic megacolon and its distribution between diabetic and non-diabetic animals in the bb rat colony in edinburgh.
Diabetes mellitus (commonly referred to as diabetes) is a medical condition that is associated with high blood sugar. It results from a lack of, or insufficiency of, the hormone insulin which is produced by the pancreas.
Activated t-lymphocyte levels in the spontaneously diabetic bb rat syndrome. About 50% of individual members of a diabetes-prone stock of bb rats eventually become hyperglycemic (usually between 60 and 180 days of age) while the remainder remain normoglycemic for life.
When compared with laboratory chow, a defined, semipurified diet prevented diabetes, reduced the frequency of insulitis, increased thymus weight and total white blood cell count, and doubled thymus t-helper/t-suppressor cell ratios in diabetes-prone bb rats. These data show that the diabetic syndrome in bb rats may be prevented or delayed by changes in diet, which may occur through alteration of pathogenic defects in the immune system.
Spontaneous diabetes mellitus in the biobreeding/worcester (bb/w) rat is preceded by lymphocytic insulitis which destroys pancreatic beta cells. Cultured major histocompatibility complex identical pancreatic islets and adrenal cortex derived from diabetes-resistant bb/w donors were transplanted into diabetic recipients with hyperglycemia of variable duration.
Diabetes impacts the lives of more than 34 million americans, which adds up to more than 10% of the population. When you consider the magnitude of that number, it’s easy to understand why everyone needs to be aware of the signs of the disea.
To investigate the metabolic fates of glutamine in splenocytes from the bb rat with spontaneous immunologically mediated insulin-dependent diabetes, freshly isolated cells were incubated in krebs.
The spontaneously diabetic bb/wor rats develop secondary complications like neuropathy as do human diabetic patients. 3 bb/wor rats treated with insulin via a subcutaneous implant show a significant impairment of sensory and motor nerve conduction velocity 6 weeks after the onset of diabetes mellitus.
Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (bio breeding/worcester) and prevented diabetes in susceptible nondiabetic.
The spontaneously diabetic bb/w-rat has emerged as an important model system for somatic and autonomic diabetic polyneuropathy. In this study we examined visual evoked potentials and the presence of morphometric and structural changes in the optic nerve and the retinal ganglion cells and their afferent axons contained in the retinal nerve fibre layer.
The purpose of this investigation was to examine cardiac sarcoplasmic reticular (sr) calcium transport and heart function in the bb rat, a strain in which diabetes occurs spontaneously and clearly.
We used the type 1 diabetic biobreeding (bb)‐rat model to study jejunal motor control and nnos expression, which is independent of the vagus. Jejunal segments were used for in vitro contractility studies, and measurement of nnos expression after 8 or 16 weeks of diabetes compared with age‐ and sex‐matched controls.
Hepatic microsomal cytochrome p-450j has been studied using the male spontaneously diabetic bb rat as a model for insulin-dependent diabetes.
Biobreeding rat also known as the bb or bbdp rat is an inbred laboratory rat strain that spontaneously develops autoimmune type 1 diabetes. Like the nod mice, bb rats are used as an animal model for type 1 diabetes. The strain re-capitulates many of the features of human type 1 diabetes, and has contributed greatly to the research of t1d pathogenesis.
A longitudinal study of 51 weanlings from 5 litters of “bb” wistar rats was undertaken to characterize the time course of the spontaneous diabetic syndrome. An abnormal glucose tolerance preceded the onset of the syndrome in 6 of these 9 rats.
Do you or someone you know suffer from diabetes? this is a condition in which your body doesn't produce or use adequate amounts insulin to function properly. It can be a debilitating and devastating disease, but knowledge is incredible medi.
The effects of spontaneous diabetes on pancreatic a, b, and d cells were assessed using immunocytochemical, and histochemical ria techniques. Three groups of un we use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies.
Jun 10, 2013 since 2008, a team of 77 african giant pouched rats have been trained by the belgian social enterprise apopo to sniff out the killer infection.
The present study examined in the spontaneously diabetic bb/ok rat whether a relationship exists between the appearance of complement‐dependent antibody‐mediated cytotoxicity (c'amc) in serum and the relative β cell volume density determined in pancreatic biopsies.
Diabetes is a metabolic disease; it is also termed diabetes mellitus. Diabetes 1 occurs when the body does not produce any insulin.
Urinary bladder function was examined in the spontaneously diabetic bb rat six months after the onset of diabetes. Diabetes caused significant decreases in rat weight and increases in bladder body weights and in vivo bladder capacities compared to age-matched controls, but no changes in the weights of bladder bases.
Peripheral nerves of the diabetic insulin-dependent bb-wistar-rat were studied ultrastructurally. Conspicuous early changes consisted of mitochondrial accu the later stages of the diabetic syndrome showed axonal dwindling and disintegration in both myelinated and unmyelinated fibers.
Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (bio breeding/worcester) and prevented diabetes in susceptible nondiabetic controls.
Diabetes which occurs spontaneously in the bb wistar rat is associated with reduced fertility, predominantly in breeding males. 05) reduction in serum testosterone associated with a transient decrease of serum lh and the accumulation of lipid in leydig cells. Between one and three months of diabetes, there is an increase in both serum testosterone and lh and a further deposition of lipid droplets in leydig cells.
Feb 1, 1988 hepatic microsomal cytochrome p-450j has been studied using the male spontaneously diabetic bb rat as a model for insulin-dependent.
The bb rat strain was derived from a colony of outbred wistar rats that developed spontaneous diabetes mellitus at the biobreeding laboratories, ottawa, canada, in the 1970s. Affected animals became the founders of the inbred diabetes‐prone (dp)‐bb/wor rat strain used in the majority of published studies.
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